Oral Tablet -> Proviron UK


Proviron-UK

Pharmaceutical Name: Proviron-UK

Chemical Name: Mesterone

Unit Available:100 Tabs

Each tablet contain: 25 mg.

Description

 

Proviron-UK is UK Pharmalab brand name for the oral androgen mesterolone (1-methyldihydrotestosterone). Similar to dihydrotestosterone, mesterolone is a strong androgen with only a weak level of anabolic activity. This is due to the fact that like dihydrotestosterone, mesterolone is rapidly reduced to inactive diol metabolites in muscle tissue where concentrations of the 3-hydroxysteroid dehydrogenase enzyme are high.The belief that the weak anabolic nature of this compound indicates a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle-building steroids, should likewise not be taken seriously. ln fact, due to its extremely high afhnity for plasma binding proteins such as SHBG, mesterolone may actually work to potentate the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes, mesterolone is primarily used to increase androgen levels when dieting or preparing for a contest, and as an anti-estrogen due to its intrinsic ability to antagonize the aromatase enzyme.

 

Structural Characteristics

 

Mesterolone is a modified form of dihydrotestosterone. lt differs by the addition of a methyl group at carbon i, which helps protect the hormone from hepatic metabolism during oral administration. The same structural modification is also used with oral methenolone tablets. Alkylation at the one position slows hepatic metabolism of the steroid during the first pass, although much less profoundly than c-17 alpha alkylation. Nlesterolone is resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability remains much lower than c-l7 alpha alkylated oral steroids. Nlesterolone also has a very strong binding affinity for Sex Hormone Binding Globulin. This may act to displace other steroids more weakly bound to SHBG into a free (active) state.

 

Dosage Recommanded

 

To treat androgen insufficiency, mesterolone is usually given in a dose of 1 tablet (25 mg) three times per day at the initiation of therapy. The drug is later continued at a
lower maintenance dose, which usually consists of taking 1 tablet (25 mg) one to two times per day. Similar doses are used to support malefertility, usually in conjunction with other fertility drugs like injectable FSH. The usual dosage among male athletes is between 50 mg and 150 mg of mesterolone per day, or two to six 25 mg tablets. The drug is typically taken in cycles of 6-12 weeks in length, which is usually a sufficient period of time to notice the benehts of drug therapy.


Many bodybuilders favor the use of mesterolone during dieting phases or contest preparation,when low estrogen and high androgen levels are particularly desirable. This is especially beneficial when anabolics like Winstrol, Anavar, or Primobolan are being used alone, as the androgenic content of these drugs is relatively low. Mesterolone can be effectively used here to adjust the androgen to estrogen ratio upwards, bringing about an increase in the hardness and density of the muscles, supporting libido and general sense of well being, and increasing the tendency to burn body fat. It is also commonly used (at a similar dosage) to prevent gynecomastia when other aromatizable steroids are being administered, often in conjunction with 10-20 mg per day of Nolvadex.


Mesterolone is not approved for use in women. This agent is not recommended for women for physique or performance-enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects. Some women do favor the drug, however, and find a single 25 mg tablet enough to efficiently shift the hormone balance in the body, greatly impacting the look of definition to the physique. Intake is usually limited to no longer than four or five weeks in such situations to minimize the chance of developing lasting virilizing effects.One tablet used in conjunction with 10 or 20 mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat, especially in female trouble areas like the hips and thighs. Extreme caution should be taken with such use, however.


Side Effects

 

Mesterolone has a very weak suppressive effect on gonadotropins and serum testosterone. Studies show that when given in moderate doses (150 mg per day or less), significant suppression of testosterone levels does not occur. In studies with higher doses (300 mg per day and above), the agent strongly suppressed serum testosterone.

 

 

Systematic name : 1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one